<?xml version="1.0" encoding="UTF-8"?><protocol_summary><protocol><id>17248</id><no>PARADIGM</no><status>Open</status><title> A Prospective rAndomized tRial Assessing the safety and &#xD;
effectiveness of the DurAVR® bIomimetic valve designed for physioloGic flow &#xD;
compared to coMmercial TAVR devices</title><secondary_protocol_no>SP0083</secondary_protocol_no><nct_id>NCT07194265</nct_id><sponsor_type>Industrial</sponsor_type><age_group>Adult</age_group><treatment_type>Treatment</treatment_type><disease_site>Other</disease_site><PI>Rogers, Toby; Wang, John</PI><institution>Medstar Union Memorial Hospital</institution><management_group>MCRN - Baltimore Inpatient; MCRN - Baltimore Outpatient; MCRN - Wash Interventional</management_group></protocol><sipVersion>2026.1.0 Build 16</sipVersion><copyright> &lt;a href="https://advarra.com" target="_blank"&gt;&amp;copy; 2026 Advarra, Inc.&lt;/a&gt; </copyright></protocol_summary>