<?xml version="1.0" encoding="UTF-8"?><protocol_summary><protocol><id>16701</id><no>CLOU064P12301</no><status>Open</status><title>A randomized, double-blind, placebo-controlled Phase III&#xD;
study to evaluate the efficacy and safety of remibrutinib in&#xD;
patients with secondary progressive multiple sclerosis</title><sponsor_type>Industrial</sponsor_type><age_group>Adult</age_group><treatment_type>Treatment</treatment_type><phase>III</phase><disease_site>Other</disease_site><PI>Barry, Brian</PI><institution>MedStar Health and GUMC; Medstar Washington Hospital Center</institution><management_group>MedStar Neuroscience &amp; Rehab Research Network</management_group></protocol><sipVersion>2026.1.0 Build 16</sipVersion><copyright> &lt;a href="https://advarra.com" target="_blank"&gt;&amp;copy; 2026 Advarra, Inc.&lt;/a&gt; </copyright></protocol_summary>