<?xml version="1.0" encoding="UTF-8"?><protocol_summary><protocol><id>16630</id><no>S2209-NCT05561387</no><status>Open</status><title>S2209: A PHASE III RANDOMIZED TRIAL FOR NEWLY DIAGNOSED MULTIPLE MYELOMA (NDMM) PATIENTS CONSIDERED FRAIL OR IN A SUBSET OF  INTERMEDIATE FIT  COMPARING UPFRONT THREE-DRUG INDUCTION REGIMENS FOLLOWED BY DOUBLE- OR SINGLE-AGENT MAINTENANCE.</title><secondary_protocol_no>S2209</secondary_protocol_no><nct_id>NCT05561387</nct_id><sponsor_type>National</sponsor_type><age_group>Adult</age_group><treatment_type>Treatment</treatment_type><phase>III</phase><scope>Global</scope><disease_site>Multiple Myeloma</disease_site><PI>Shenoy, Aarthi</PI><institution>MedStar Health and GUMC; Medstar Washington Hospital Center</institution><oncology_group>Multiple Myeloma<DOWG_name>Oncology Group</DOWG_name></oncology_group><management_group>MHRI Washington Cancer Institute</management_group></protocol><sipVersion>2026.1.0 Build 16</sipVersion><copyright> &lt;a href="https://advarra.com" target="_blank"&gt;&amp;copy; 2026 Advarra, Inc.&lt;/a&gt; </copyright></protocol_summary>