<?xml version="1.0" encoding="UTF-8"?><protocol_summary><protocol><id>16394</id><no>EFC17872</no><status>Open</status><title>A 52-week, multicenter, randomized, double-blind, placebocontrolled,&#xD;
parallel-group, group sequential, Phase 3 study to&#xD;
evaluate the efficacy and safety of rilzabrutinib in patients aged&#xD;
10 to 65 years with sickle-cell disease (LIBRA)</title><sponsor_type>Industrial</sponsor_type><age_group>Adult</age_group><treatment_type>Treatment</treatment_type><phase>III</phase><disease_site>Other</disease_site><PI>Broome, Catherine</PI><institution>Georgetown University Medical Center; Lombardi Comprehensive Cancer Center</institution><management_group>GUMC Medicine Hem-Onc</management_group></protocol><sipVersion>2026.1.0 Build 16</sipVersion><copyright> &lt;a href="https://advarra.com" target="_blank"&gt;&amp;copy; 2026 Advarra, Inc.&lt;/a&gt; </copyright></protocol_summary>