<?xml version="1.0" encoding="UTF-8"?><protocol_summary><protocol><id>16220</id><no>AVZO-1418-1001-NCT07038343</no><status>Open</status><title>A phase 1/2, first in human study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and anti-tumor activity of AVZO-1418 as a single agent and in combination therapy in patients with locally advanced or metastatic solid tumors</title><secondary_protocol_no>AVZO-1418-1001</secondary_protocol_no><nct_id>NCT07038343</nct_id><sponsor_type>Industrial</sponsor_type><age_group>Adult</age_group><treatment_type>Treatment</treatment_type><phase>I/II</phase><disease_site>Multiple</disease_site><PI>Liu, Stephen</PI><institution>Georgetown University Medical Center; Lombardi Comprehensive Cancer Center</institution><oncology_group>Phase I<DOWG_name>Oncology Group</DOWG_name></oncology_group><management_group>Lombardi Comprehensive Cancer Center (LCCC)</management_group></protocol><sipVersion>2026.1.0 Build 16</sipVersion><copyright> &lt;a href="https://advarra.com" target="_blank"&gt;&amp;copy; 2026 Advarra, Inc.&lt;/a&gt; </copyright></protocol_summary>