<?xml version="1.0" encoding="UTF-8"?><protocol_summary><protocol><id>15868</id><no>KRT-232-115</no><status>Open</status><title>A Phase 3, Randomized, Double-blind, Add-on Study Evaluating the Safety and Efficacy of Navtemadlin Plus Ruxolitinib vs Placebo Plus Ruxolitinib in JAK Inhibitor-Naïve Patients with Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib</title><nct_id>NCT06479135</nct_id><sponsor_type>Industrial</sponsor_type><age_group>Adult</age_group><treatment_type>Treatment</treatment_type><phase>III (Cancer Control)</phase><cancer_control>Y</cancer_control><scope>Global</scope><disease_site>Other</disease_site><PI>Cunningham, Julia</PI><institution>Georgetown University Medical Center; Lombardi Comprehensive Cancer Center</institution><oncology_group>Cell Therapy; Leukemia<DOWG_name>Oncology Group</DOWG_name></oncology_group><management_group>Lombardi Comprehensive Cancer Center (LCCC)</management_group></protocol><sipVersion>2026.1.0 Build 16</sipVersion><copyright> &lt;a href="https://advarra.com" target="_blank"&gt;&amp;copy; 2026 Advarra, Inc.&lt;/a&gt; </copyright></protocol_summary>