<?xml version="1.0" encoding="UTF-8"?><protocol_summary><protocol><id>15675</id><no>RP1-104-IGNYTE-3</no><status>Open</status><title>A Randomized, Controlled, Multicenter, Phase 3 Clinical Study Comparing Vusolimogene Oderparepvec in Combination with Nivolumab Versus Treatment of Physician s Choice in Patients with Advanced Melanoma That Has Progressed on an Anti-PD-1 and an Anti-CTLA-4 Containing Treatment Regimen [IGNYTE-3]</title><secondary_protocol_no>RP1-104</secondary_protocol_no><nct_id>NCT06264180</nct_id><sponsor_type>Industrial</sponsor_type><age_group>Adult</age_group><treatment_type>Treatment</treatment_type><phase>III</phase><scope>Global</scope><disease_site>Melanoma, Skin</disease_site><PI>Rapisuwon, Suthee</PI><institution>MedStar Health and GUMC; Medstar Washington Hospital Center</institution><oncology_group>Melanoma<DOWG_name>Oncology Group</DOWG_name></oncology_group><management_group>MHRI Washington Cancer Institute</management_group></protocol><sipVersion>2026.1.0 Build 16</sipVersion><copyright> &lt;a href="https://advarra.com" target="_blank"&gt;&amp;copy; 2026 Advarra, Inc.&lt;/a&gt; </copyright></protocol_summary>