<?xml version="1.0" encoding="UTF-8"?><protocol_summary><protocol><id>15527</id><no>MCLA-158-CL02-MWHC</no><status>Open</status><title>A phase 3 open-label, randomized, controlled study to evaluate the efficacy and safety of petosemtamab compared with investigator s choice monotherapy treatment in previously treated patients with incurable, metastatic/recurrent head and neck squamous cell carcinoma</title><secondary_protocol_no>MCLA-158-CL02</secondary_protocol_no><nct_id>NCT06496178</nct_id><sponsor_type>Industrial</sponsor_type><age_group>Adult</age_group><treatment_type>Treatment</treatment_type><phase>III</phase><scope>Global</scope><disease_site>Lip, Oral Cavity and Pharynx</disease_site><PI>Merkhofer, Cristina</PI><institution>MedStar Health and GUMC; Medstar Washington Hospital Center</institution><oncology_group>Thoracic/CNS/H&amp;N/Thyroid<DOWG_name>Oncology Group</DOWG_name></oncology_group><management_group>MHRI Washington Cancer Institute</management_group></protocol><sipVersion>2026.1.0 Build 16</sipVersion><copyright> &lt;a href="https://advarra.com" target="_blank"&gt;&amp;copy; 2026 Advarra, Inc.&lt;/a&gt; </copyright></protocol_summary>