<?xml version="1.0" encoding="UTF-8"?><protocol_summary><protocol><id>15357</id><no>VS01-IIA-01</no><status>Open (affiliates only)</status><title>A Phase 2a, open-label, randomized, controlled, multicenter, proof of concept study, to assess the efficacy, safety and tolerability of VS-01 on top of standard of care, compared to standard of care alone, in adult patients with acute-on-chronic liver failure (ACLF) grades 1 and 2 and ascites</title><secondary_protocol_no>VS01-IIa-01</secondary_protocol_no><nct_id>NCT05900050</nct_id><sponsor_type>Industrial</sponsor_type><age_group>Adult</age_group><treatment_type>Treatment</treatment_type><phase>II</phase><scope>Global</scope><disease_site>Other</disease_site><PI>Thomas, Arul</PI><institution>Georgetown University Medical Center; Lombardi Comprehensive Cancer Center</institution><management_group>GUMC Transplant</management_group></protocol><sipVersion>2026.1.0 Build 16</sipVersion><copyright> &lt;a href="https://advarra.com" target="_blank"&gt;&amp;copy; 2026 Advarra, Inc.&lt;/a&gt; </copyright></protocol_summary>