A Phase III Adjuvant Trial Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression plus Endocrine Therapy in Premenopausal Patients with pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score ≤ 25 (OFSET)

15264NRG-BR009-NCT05879926OpenA Phase III Adjuvant Trial Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression plus Endocrine Therapy in Premenopausal Patients with pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score ≤ 25 (OFSET)NRG-BR009NCT05879926NationalAdultTreatmentIIIBreastWhitaker, KristenGeorgetown University Medical Center : Julie Castle, Antonella Novielli; Lombardi Comprehensive Cancer Center : Julie Castle, Antonella Novielli; MedStar Health and GUMC; Medstar Franklin Square Medical Center; Medstar Good Samaritan Hospital; Medstar Montgomery Medical Center; Medstar Washington Hospital CenterBreastOncology GroupLombardi Comprehensive Cancer Center (LCCC); MHRI Washington Cancer Institute7263Julie CastleJulie Castle+1 202-687-2209bickmorj@georgetown.eduClinical Research Nurse 7311Antonella NovielliAntonella Novielli+1 202-784-3923+1 202-687-3372noviella@georgetown.eduClinical Research Nurse 2026.1.0 Build 16 <a href="https://advarra.com" target="_blank">© 2026 Advarra, Inc.</a>