<?xml version="1.0" encoding="UTF-8"?><protocol_summary><protocol><id>14661</id><no>D3460C00002</no><status>Open</status><title>A Multicenter, Randomized, Parallel-group, Double-blind, Two-arm, Phase III Study to Evaluate the Safety and Efficacy of Anifrolumab Compared with Placebo in Male and Female Participants 18 to 70 years of Age inclusive with Systemic Sclerosis</title><nct_id>NCT05925803</nct_id><sponsor_type>Industrial</sponsor_type><age_group>Adult</age_group><treatment_type>Treatment</treatment_type><phase>III</phase><disease_site>Diseases Of The Musculoskeletal System And Connective Tissue</disease_site><PI>Steen, Virginia</PI><institution>Georgetown University Medical Center; Lombardi Comprehensive Cancer Center</institution><management_group>GUMC Medicine Rheumatology; GUMC PFS</management_group></protocol><sipVersion>2026.1.0 Build 16</sipVersion><copyright> &lt;a href="https://advarra.com" target="_blank"&gt;&amp;copy; 2026 Advarra, Inc.&lt;/a&gt; </copyright></protocol_summary>