<?xml version="1.0" encoding="UTF-8"?><protocol_summary><protocol><id>13867</id><no>SPYRALAFFIRM</no><status>Open (affiliates only)</status><title>The SPYRAL AFFIRM Global Clinical Study of Renal Denervation with the&#xD;
Symplicity Spyral Renal Denervation System in Subjects with Uncontrolled&#xD;
Hypertension (SPYRAL AFFIRM)</title><sponsor_type>Industrial</sponsor_type><age_group>Adult</age_group><treatment_type>Treatment</treatment_type><disease_site>Hypertension</disease_site><PI>Bernardo, Nelson</PI><institution>Medstar Washington Hospital Center</institution><management_group>MCRN - Peripheral Vascular</management_group></protocol><sipVersion>2026.1.0 Build 16</sipVersion><copyright> &lt;a href="https://advarra.com" target="_blank"&gt;&amp;copy; 2026 Advarra, Inc.&lt;/a&gt; </copyright></protocol_summary>