<?xml version="1.0" encoding="UTF-8"?><protocol_summary><protocol><id>13685</id><no>NRG-GI008-NCT05174169</no><status>Open</status><title>Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease</title><objective>This Phase II/III trial will evaluate the what kind of chemotherapy to recommend to patients based on the presence or absences of circulating tumor DNA (ctDNA) after surgery for colon cancer.&#xD;
</objective><secondary_protocol_no>NRG-GI008</secondary_protocol_no><nct_id>NCT05174169</nct_id><sponsor_type>Industrial; National</sponsor_type><age_group>Adult</age_group><treatment_type>Treatment</treatment_type><treatment>Device: Signatera test&#xD;
Drug: mFOLFOX6 3-6 month&#xD;
Drug: CAPOX 3 month&#xD;
Drug: mFOLFIRINOX&#xD;
Drug: mFOLFOX6 6 month&#xD;
Drug: CAPOX 6 month</treatment><phase>II/III</phase><scope>National</scope><disease_site>Colon</disease_site><lay_description>This study investigates the following conditions or diseases: Stage III Colon Cancer&#xD;
</lay_description><PI>Weinberg, Benjamin</PI><institution>Georgetown University Medical Center : Susan Lawrence; Lombardi Comprehensive Cancer Center : Susan Lawrence; Medstar Franklin Square Medical Center; Medstar Good Samaritan Hospital; Medstar Montgomery Medical Center; Medstar Washington Hospital Center</institution><oncology_group>Gastrointestinal<DOWG_name>Oncology Group</DOWG_name></oncology_group><management_group>Lombardi Comprehensive Cancer Center (LCCC)</management_group><item><contact_id>17105</contact_id><item_description>Susan Lawrence</item_description><js_safe_str>Susan Lawrence</js_safe_str><email>sl2328@georgetown.edu</email></item></protocol><sipVersion>2026.1.0 Build 16</sipVersion><copyright> &lt;a href="https://advarra.com" target="_blank"&gt;&amp;copy; 2026 Advarra, Inc.&lt;/a&gt; </copyright></protocol_summary>