13383ALLIANCE-NCT05172960OpenThe objective of this study is to establish the safety and effectiveness of the Edwards SAPIEN X4 Transcatheter Heart Valve (THV) in subjects with symptomatic, severe, calcific aortic stenosis (AS). NCT05172960IndustrialAdultTreatmentDevice: SAPIEN X4 THV N/ANonrheumatic aortic (valve) stenosisAortic Stenosis, Severe Wang, JohnMedStar Health and GUMC; Medstar Union Memorial HospitalMCRN - Baltimore Inpatient2026.1.0 Build 16 <a href="https://advarra.com" target="_blank">&copy; 2026 Advarra, Inc.</a>