<?xml version="1.0" encoding="UTF-8"?><protocol_summary><protocol><id>12227</id><no>RPNI</no><status>Open</status><title> Regenerative Peripheral Nerve Interfaces to Treat Painful Digit and Hand Neuromas After Amputation: A Randomized, Prospective Study</title><objective>This study is being done to demonstrate the effectiveness of Regenerative Peripheral Nerve Interfaces (RPNI) surgery in treating symptomatic neuromas of the hand and digits following amputation compared to standard of care using a prospective, randomized trial.</objective><secondary_protocol_no>Pro00049513</secondary_protocol_no><nct_id>NCT05008185</nct_id><sponsor_type>Externally Peer-Reviewed</sponsor_type><age_group>Adult</age_group><treatment_type>Treatment</treatment_type><treatment>Procedure: Regenerative Peripheral Nerve Interface (RPNI) surgery&#xD;
Procedure: Traction Neurectomy</treatment><scope>National</scope><disease_site>Other</disease_site><lay_description>This study investigates the following condition or disease: Neuroma </lay_description><PI>Giladi, Aviram</PI><institution>Medstar Union Memorial Hospital</institution><management_group>MedStar Orthopedics &amp; Sports Research Network</management_group></protocol><sipVersion>2026.1.0 Build 16</sipVersion><copyright> &lt;a href="https://advarra.com" target="_blank"&gt;&amp;copy; 2026 Advarra, Inc.&lt;/a&gt; </copyright></protocol_summary>